Folic acid 5mg ဖောလစ်အက်ဆစ် အားဆေး
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Product Details
ဖောလစ်အက်ဆစ် အားဆေး ဖြစ်ပြီး သွေးအားနည်းသူများ ကိုယ်ဝန်ဆောင်မိခင်များ တနေ့တလုံး ပုံမှန် သောက်သုံး၍ ရပါသည်
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Indications and Dosage
Oral
Prophylaxis of neural tube defect in pregnancy
Adult: 5 mg daily starting 4 weeks before pregnancy and continued through the 1st trimester.
Oral Folate-deficient megaloblastic anaemia
Adult: 5 mg daily for up to 4 months. May increase to 15 mg daily in malabsorption states. Maintenance: 5mg every 1-7 days.
Child: >1 year Same as adult dose Parenteral Folate-deficient megaloblastic anaemia
Adult: Up to 1 mg daily given via IM/IV/SC inj. Maintenance: 0.4 mg daily.
Child: Same as adult dose. Maintenance: Infants: 0.1 mg daily; <4 years Up to 0.3 mg daily; >4 years 0.4 mg daily. |
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Administration
May be taken with or without food.
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Contraindications
Untreated pernicious anaemia, untreated cobalamin deficiency or other cause of cobalamin deficiency.
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Special Precautions
Patients with folate-dependent tumours.
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Adverse Reactions
Cardiac disorders: Flushing.
Gastrointestinal disorders: Anorexia, nausea, abdominal distention, flatulence. Immune system disorders: Allergic reactions. Nervous system disorders: Malaise. Respiratory, thoracic and mediastinal disorders: Bronchospasm. Skin and subcutaneous tissue disorders: Erythema, pruritus, skin rash, hypersensitivity. |
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Monitoring Parameters
Perform cobalamin absorption test for elderly prior to initiation of therapy.
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Drug Interactions
May decrease concentration of phenytoin. Decreased absorption with sulfasalazine and triamterene. Chloramphenicol, methotrexate and co-trimoxazole may interfere with folate metabolism. May enhance efficacy of lithium.
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Action
Description: Folic acid is essential for the production of coenzymes in many metabolic systems such as purine and pyrimidine synthesis. It is also essential in nucleoprotein synthesis, maintenance of erythropoiesis and stimulation of WBC and platelet production in folate-deficiency anaemia.
Onset: 0.5-1 hour (oral). Pharmacokinetics: Absorption: Rapidly absorbed from the proximal part of small intestine. Bioavailability: Approx 100% (folic acid supplement); 85% (with food); 50% (dietary folate). Time to peak plasma concentration: 1 hour (oral). Distribution: Distributed to body tissues and stored in the liver. Actively concentrated in the CSF, and enters breast milk. Extensively bound to plasma protein. Metabolism: Metabolised in the liver and plasma to active metabolite, 5- methyltetrahydrofolate. Undegoes enterohepatic circulation. Excretion: Via urine. |
Folic acid 5mg ဖောလစ်အက်ဆစ် အားဆေး
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