Keppra 250mg- Levetiracetam GSK အတက်ရောဂါများအတွက်ဆေး
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Keppra 250mg- Levetiracetam GSK အတက်ရောဂါများအတွက်ဆေး

Home/Store/BCX-i Pharmacy ဆေးနှင့်ဆေးပစ္စည်များ/ဆေးအမျိုးအမည်များ Products of Medicine/Anticonvulsant အတက်ရောဂါများအတွက်ဆေးများ
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Product Details
Brand: GSK Belgium

အတက်ရောဂါများအတွက် သီးသန့်ဆေးဖြစ်ပြီး ဆရာဝန် ညွှန်ကြားချက်ဖြင့်သာသောက်ရန်

Oral
Partial seizures with or without secondary generalisation
Adult: Monotherapy: Recommended starting dose is 250 mg bid, increased to an initial therapeutic dose of 500 mg bid after 2 wk. May further increase by 250 mg bid every 2 wk depending upon response. Max: 1,500 mg bid.

Oral
Adjunct in seizures
Adult: For partial seizures w/ or w/o secondary generalisation; myoclonic seizures (w/ juvenile myoclonic epilepsy); primary generalised tonic-clonic seizures (w/ idiopathic generalised epilepsy): Initially, 500 mg bid on the 1st day. Adjust dose in increments or decrements of 500 mg bid at 2-4 wk intervals. Max: 1,500 mg bid.
Child: 1 to <6 mth Initially, 14 mg/kg daily, may adjust in increments of 14 mg/kg at 2-wk intervals. Max: 42 mg/kg daily; ≥6 mth <50 kg: Initially, 20 mg/kg daily, may adjust in increments of 20 mg/kg at 2-wk intervals. Max: 60 mg/kg daily.
Renal Impairment
ESRD patients undergoing dialysis: Loading dose of 750 mg, followed by 500-1,000 mg once daily; supplemental dose of 250-500 mg after dialysis.
CrCl (mL/min) Dosage
<30 250-500 mg bid.
30-49 250-750 mg bid.
50-79 500-1,000 mg bid.
Hepatic Impairment
Severe: Reduce dose by 50%.
Administration
May be taken with or without food. Oral soln may be taken directly or diluted in a glass of water.
Reconstitution
Intravenous:
Dilute dose in 100 mL of suitable diluent (e.g. NaCl 0.9%, lactated Ringer's or dextrose 5% inj).
Special Precautions
Avoid abrupt withdrawal. Renal and/or severe hepatic impairment. Pregnancy and lactation.
Adverse Reactions
Somnolence, weakness, dizziness, anorexia, diarrhoea, dyspepsia, nausea, wt gain or loss, myalgia, ataxia, headache, amnesia, depression, emotional lability, insomnia, nervousness, tremor, vertigo, diplopia, rash; paraesthesia, pancreatitis, hepatic failure, hepatitis, common colds, upper resp tract infections, alopecia, blood dyscrasias (e.g. neutropenia, pancytopenia, thrombocytopenia). Rarely, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Pregnancy Category (US FDA)
IV/Parenteral/PO: C
Patient Counseling Information
This drug may cause somnolence or other CNS related symptoms, if affected, do not drive or operate machinery.
Monitoring Parameters
Monitor for emergence or worsening of depression, suicidal thoughts or behaviour and/or unusual changes in mood or behaviour.
Overdosage
Symptoms: Somnolence, agitation, aggression, depressed level of consciousness, resp depression, coma. Management: Symptomatic and supportive treatment. Empty the stomach by gastric lavage or induction of emesis. May perform haemodialysis.
Drug Interactions
Increased or prolonged blood methotrexate concentration to potentially toxic levels.
Action
Description: The exact mechanism of anticonvulsant effect is unknown. Studies show that levetiracetam affects intraneuronal Ca levels by partial inhibition of N-type Ca currents and by reducing the release of Ca from intraneuronal stores; facilitates GABA-ergic inhibitory transmission through displacement of negative modulators; reduces delayed rectifier K current; and/or binds to synaptic proteins which modulate neurotransmitter release.
Pharmacokinetics:
Absorption: Rapidly absorbed from GI tract. Bioavailability: Approx 100%. Time to peak plasma concentration: W/in 1.3 hr.
Distribution: Distributed in breast milk. Volume of distribution: 0.5-0.7 L/kg. Plasma protein binding: <10%.
Metabolism: Not extensively metabolised; 24% of the dose is metabolised by enzymatic hydrolysis into inactive metabolites.
Excretion: Via urine (approx 95%) both as unchanged drug and metabolites; faeces (0.3%). Plasma elimination half-life: Approx 7 hr.
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Keppra 250mg- Levetiracetam GSK အတက်ရောဂါများအတွက်ဆေး
Home/Store/BCX-i Pharmacy ဆေးနှင့်ဆေးပစ္စည်များ/ဆေးအမျိုးအမည်များ Products of Medicine/Anticonvulsant အတက်ရောဂါများအတွက်ဆေးများ
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